Aliasger K. Salem

Research Interests:
Tissue Engineering
Drug Delivery
Polymeric Biomaterials
Immunocancer Therapy
Nano and Microtechnology

Personal Webpage

Dr. Salem's research interests are primarily focused on self-assembling systems, the rational design of novel drug and gene delivery systems and on the development of sophisticated scaffolds for tissue-specific regeneration. In tissue engineering, Dr Salem's laboratory applies microfabrication techniques to novel biomaterials to provide spatial control over tissue formation and to integrate minimally invasive scaffold delivery strategies. In drug/gene delivery, he is currently exploring the synergistic application of degradable particle technology, adjuvants such as CpG oligonucleotides and heat shock protein therapy for generating sustained CD8+ specific immune responses against cancers.

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Selected Publications

1. A.K. Salem, C.F. Hung, T.W. Kim, T.C. Wu, P.C. Searson, K.W. Leong. Multi-Component Nanorods for Vaccination Applications. Nanotechnology. 4 (16): 484-487 APR 2005

2. A. Hultgren, M. Tanase, E.J. Felton, K. Bhadriraju, A.K. Salem, C.S. Chen, D.H. Reich. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology Progress. (21): 509-515 APR 2005

3. A.K. Salem, M. Chen, J. Hayden, K.W. Leong, and P.C. Searson. Directed assembly of multi-segment Au/Pt/Au nanowires. Nanoletters. 4 (6): 1163-1165 JUN 2004

4. A.K. Salem, J. Chao, K.W. Leong, and P.C. Searson. Receptor mediated self-assembly of multi-component magnetic nanowires. Advanced Materials. 16 (3): 268+ FEB 3 2004

5. A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials. Oct 2003, 2, 668-671

6. H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte Inspired Therapeutic Particles that Selectively and Avidly Adhere to Inflamed Endothelium in Vitro and in Vivo. Proceedings of the National Academy of Sciences. 100 (26): 15895-15900 DEC 23 2003

7. A.K. Salem, F.R.A.J. Rose, R. Oreffo, X. Yang, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff. Porous polymer and cell composites that self assemble in situ. Advanced Materials. 15 (3): 210-213 FEB 5 2003

8. A.K. Salem, R. Stevens, R.G. Pearson, M.C. Davies, S.J.B. Tendler and K.M. Shakesheff. Interactions of 3T3 fibroblasts and endothelial with defined pore features. Journal of Biomedical Materials Research. 61 (2) 212-217 Aug 2002

9. A.K. Salem, S.M. Cannizzaro, M.C. Davies, S.J.B. Tendler, C.J. Roberts, P.M. Williams and K.M. Shakesheff. Synthesis and characterisation of a degradable biotinylated polylactic acid-polyethylene glycol copolymer. Biomacromolecules. Sum 2001, 2, 575-580.

10. A.K.Salem and K.W. Leong. Polymer Scaffolds for Tissue Engineering and Gene Delivery. Invited Chapter in the Book entitled "Scaffolding in Tissue Engineering". Marcel Dekker Edited by: Jennifer Elisseeff and Peter X. Ma