S. Ramaswamy
Associate Professor (2005)
Jointly appointed in the Biochemistry and Chemical and Biochemical Engineering
Ph.D. 1992, Indian Institute of Science
Office: 4-612 Bowen Science Bldg.
319/335-7917; fax: 319/335-9570
E-mail: s-ramaswamy@uiowa.edu
Lab Web Site: s-ramaswamy@uiowa.edu
Research Interests:
protein crystallography
structural enzymology of naphthalene dioxygenase
and alcohol dehydrogenase
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Selected Publications
Johansson, K., El-Ahmad, M., Kaiser, C., Jornvall, H., Eklund, H., Hoog, J., and Ramaswamy, S. (2001) Crystal structure of sorbitol dehydrogenase. Chem. Biol. Interact. 130-132: 351-358.
Johansson, K. Ramaswamy, S. Ljungcrantz, C., Knecht, W., Pikur, J., Munch-Petersen, B., Staffan Eriksson, S., and Eklund, H. (2001) Structural basis for substrate specificites of cellular deoxyribonucleoside kinases. Nature Struct. Biol. 8: 616-620.
Rubach, J.K., Ramaswamy, S., and Plapp, B.V. (2001) Contributions of valine-292 in the nicotinamide binding site of liver alcohol dehydrogenase and dynamics to catalysis. Biochemistry 40: 12686-12694.
Terwisscha van Scheltinga, A.C., Valegard, Ramaswamy, S., Hajdu, J., and Andersson, I. (2001) Multiple isomorphous replacement on merohedral twins: structure determination of deacetoxycephalosporin C synthease. Acta Crystallographica Section D-Biological Crystallography 57: 1176-1785.
Dai, S.D., Schwendtmayer, C., Schurmann, P., Ramaswamy, S., and Eklund, H. (2000) Redox signaling in chloroplasts: Cleavage of disulfides by an iron-sulfur cluster. 287: 655-658.
Karlsson, A., Parales, J.V., Parales, R.E., Gibson, D.T., Eklund, H., and Ramawamy, S. (2000) The reduction of the Rieske iron-sulfur cluster in naphthalene dioxygenase by X-rays. J. Inorg. Biochem. 78: 83-87.
Carredono, E., Kauppi, B., Choudhury, D., and Ramaswamy, S. (2000) Psuedosymmetry characterization in the rhombohedral crystal form of naphthalene dioxygenease. Acta Crystallographica D56: 313-321.
Carredano, E., Karlsson, A., Kauppi, B., Choudhury, D., Parales, R.E., Parales, J.V., Lee, K., Gibson, D.T., Eklund, H., and Ramaswamy, S. (2000) Substrate binding site of naphthalene 1,2-dioxygenase: Functional implications of Indole binding. J. of Mol. Biol. 296: 701-712.
S. Ramaswamy, Doo-Hong Park, and Bryce V. Plapp (1999) Substitutions in a flexible loop of horse liver alcohol dehydrogenase hinder the conformational change and unmask hydrogen transfer. Biochemistry 38: 13951-13959.
Kauppi, B., Lee, K., Carredano, E., Parales, R.E., Gibson, D.T., Eklund, H., and Ramaswamy, S. (1998) Structure of an aromatic ring-hydroxylating dioxygenase - naphthalene 1,2-dioxygenase. Structure 6 (5): 571-587.
Lee, K., Kauppi, B., Parales, R.E., Gibson, D., and Ramaswamy, S. (1997) Purification and crystallization of the oxygenase component of napthalene dioxygenase in native and selenomethionine-derivatised forms. Biochemical and Biophysical Research Communications 241: 553-557.
Cho, H., Ramaswamy, S., and Plapp, B.V. (1997) Flexibility of liver alcohol dehydrogenase in stereoselective binding of 3-butylthiolane 1-oxides. Biochemistry 36: 382-389.
Ramaswamy, S., Scholze, M. and Plapp, B.V. (1997) Binding of formamides to liver alcohol dehydrogenase. Biochemistry 36: 3522-3527.