Jennifer Fiegel

Research Interests:
Research in Dr. Jennifer Fiegel's laboratory focuses on the development of novel drug delivery systems for diseases of the lung, with special emphasis on infectious and inflammatory diseases. Through experimental studies and mathematical modeling, the laboratory designs medical aerosols with an improved ability to target the delivery of therapeutics within the lungs and explores the complex physical interactions between these delivery systems and various cells and fluids native to the lungs. The group is also investigating new ways to suppress the transmission of airborne pathogens via local variations in the lung lining fluid.

Research Website

Selected Publications

J. Fiegel, R. Clarke, D. Edwards. Airborne infectious disease and the suppression of exhaled aerosols [review]. Drug Discovery Today. 2006; 11(1-2):51-57.

D.A. Edwards, J. Fiegel, W. DeHaan, M. Brande, J. Man, R. Clarke. Novel inhalants for control and protection against airborne infections [review]. Respiratory Drug Delivery 2006. 1: 41-48.

J. Fiegel, F. Jin, J. Hanes, K. Stebe. Wetting of a particle in a thin film. J. Colloid Interface Sci. 2005; 291(2):507-514.

J. Fiegel, J. Fu, J. Hanes. Poly(ether-anhydride) microparticle aerosolization improved by controlling particle surface properties. J. Control. Release. 2004; 96(3):411-423.

J. Fu, J. Fiegel, J. Hanes. Synthesis and characterization of PEG-based ether-anhydride terpolymers: Novel polymers for pulmonary drug delivery. Macromolecules; 2004. 37(19): 7174-7180.

J. Fiegel, C. Ehrhardt, U.F. Schaefer, C.-M. Lehr, J. Hanes. Large porous particle impingement on lung epithelial cell monolayers: Toward improved particle characterization in the lung. Pharm. Res. 2003; 20(5):788-796.

J. Hanes, M. Dawson, Y. Har-el, J. Suh, and J. Fiegel. Gene Therapy in the Lung. In: A. J. Hickey (ed.) Pharmaceutical Inhalation Aerosol Technology, 2nd edition. Vol. 134. New York: Marcel Dekker Inc. 2003.

J. Fu, J. Fiegel, E. Krauland, J. Hanes. New polymer carriers for pulmonary drug delivery. Biomaterials 2002; 23(22):4425-4433.

C. Ehrhardt, J. Fiegel, S. Fuchs, R. Abu-Dahab, U.F. Schaefer, J. Hanes, C.-M. Lehr. Drug absorption by the respiratory mucosa – Cell culture models and particulate drug carriers. J. Aerosol Med. 2002; 15(2):131-139.

C. Ehrhardt, C. Kneuer, J. Fiegel, J. Hanes, U.F. Schaefer, K.-J. Kim, C.-M. Lehr. Influence of apical fluid volume on the development of functional cellular junctions in the human bronchial epithelial cell line 16HBE14o-: implications for the use as an in vitro model for drug absorption. Cell & Tissue Research 2002; 308:391-400.